N-terminal pro-Brain Natriuretic Peptide Brain natriuretic peptides (BNP) are produced initially as a 134 amino acid pre-pro-peptide, which is cleaved into proBNP as 108 amino acids. This precursor molecule is stored in secretary granules in myocytes. Upon release, proBNP is cleaved by a protease into N-terminal (NT)-proBNP (a 76 amino acid, biologically-inert portion), and BNP (which is biologically active). The highest concentrations of NT-proBNP and BNP are found in the left ventricular (LV) myocardium, but are also detectable in arterial tissue and the myocardium of the right ventricle. A significant body of evidence has developed to demonstrate that NT-proBNP and BNP levels correlate with diagnosis, clinical status, and prognosis in congestive heart failure (CHF).
Technology: Immunochromatography Turn Around Time: 15 minutes Sample Type: Whole Blood, Plasma, or Serum Volume of Sample Required: 80 Î¼l Storage: Room Temperature (2-30 â„ƒ) Shelf Life: 15 months Package: 20 test cassettes / box Box Contents: 20 test cassettes, 20 micro pipettes, 1 instruction manual
Catalogue No.: CD7154
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